Please be aware that this researches summary is not intended to make any claim of the efficacy of pine pollen powder, but as a reference for our clients when you want to choose pine pollen supplement. All below researches were clinical studies in cells, mice, rats and other small animals only.
Effects of pine pollen wall on gut microbiota and biomarkers in mice with dyslipidemia
The pollen of Pinus yunnanensis has abundant physiological functions. However, whether pine pollen plays a beneficial role in human body has not been studied. The researchers analyzed its effects on the metabolism and intestinal microbiota of dyslipidemia mouse model. Studies have found that pine pollen intake can prevent liver pathological changes and reduce TNF- α、 Concentrations of IL-6, TC and HDL cholesterol. In addition, it can regulate bile acid and fat metabolism, SCFAs content and the structure of intestinal microbiota. According to the changes of carbohydrate metabolites, the researchers speculate that cellulose should be the main component to play the above beneficial effects, while sporopollen can not be used in the intestine.
The Potential Effects and Use of Chinese Herbal Medicine Pine Pollen ( Pinus pollen): A Bibliometric Analysis of Pharmacological and Clinical Studies
The purpose of this study is to conduct a comprehensive literature search and bibliometric analysis to determine the breadth and number of pharmacological and clinical studies of pine pollen, and to determine the potential role and use of pine pollen. Three Chinese electronic databases and two English electronic databases were searched for pharmacological and clinical studies of pine pollen. Of the 239 publications identified, 180 were pharmacological studies, 37 were clinical trials, and 22 were reviews. The number of publications has increased particularly since 2004. The ten most common topics in the pharmacological research of pine pollen are immune regulation, anti-aging, anti-oxidation, liver protection, inhibition of prostate hyperplasia, inhibition of tumor cell proliferation, reduction of blood glucose, reduction of blood lipid, anti fatigue and improvement of intestinal function. The top 10 most common clinical diseases treated or used pine pollen as adjuvant are bedsore, diaper dermatitis, hyperlipidemia, oral mucositis, eczema, prostatic hyperplasia, hypertension, prostatitis, type 2 diabetes and radioactive dermatitis. Eight trials reported no adverse events related to pine pollen, and one reported a slight gastrointestinal reaction, but the symptoms disappeared without special treatment. In the past 20 years, there have been more and more publications on pine pollen. Pharmacological studies have shown many potential benefits, and clinical studies have shown that it can produce some positive effects when used as a single herb or adjuvant in the treatment of diseases. As an external drug, especially for the treatment of skin diseases, it deserves attention.
Allergenicity and cross-reactivity of pine pollen
Pine pollen has long been considered as a non allergic pollen. The large volume and low protein level of grains are the main reasons for this hypoallergenicity. The purpose of this study was to describe the main hypersensitive zones of Pinus radiata (PR) and their cross reactions with other pine, conifer and grass pollen.
The research shown that pine pollen should be considered as potentially allergic pollen, especially in pollen rich areas. The detection of a large number of pine pollen single sensitized patients shows that it is possible to carry out specific immunotherapy for these patients.
Preclinical Study on the Hepatoprotective Effect of Pollen Extract of Pinus brutia Ten. (Red Pine) in Mice and Phenolic Acid Analysis
The results of this study led us to conclude that red pine(Pinus brutia Ten.) pollen extract can be used as a promising liver protector. Among the phenolic acids analyzed in the pollen extract, vanillic acid is the main phenolic acid in addition to other phenolic acids detected, which seems to be the reason for its significant hepatoprotective effect.
Pine pollen polysaccharides promote cell proliferation and accelerate wound healing by activating the JAK2-STAT3 signaling pathway
Natural drugs have the excellent characteristics of promoting rapid wound healing, and can be used to develop wound healing agents. Pine pollen polysaccharide is a water-soluble polysaccharide with hydrophilicity and viscosity, which is suitable for the development of wound dressings. The purpose of this study was to investigate the role and mechanism of pine pollen polysaccharides in wound healing. The results showed that pine pollen polysaccharide could promote wound healing, promote cell proliferation, change cell cycle from G1 phase to S phase and G2 phase, and increase the expression of cyclin B1. These effects of pine pollen polysaccharides are realized by activating jak2-stat3 signaling pathway. Similarly, pine pollen polysaccharide can accelerate the healing of skin wounds in mice and promote the growth of chorioallantoic blood vessels in chicken embryos. In conclusion, this study shows that pine pollen polysaccharide is a promising new natural drug to promote wound healing.
Polysaccharides from Pinus massoniana pollen improve intestinal mucosal immunity in chickens
Taishan masson pine pollen polysaccharide is an effective vaccine adjuvant and potential immune enhancer for virus infection. In this study, polysaccharide was extracted from Pinus massoniana pollen in Taishan to study its promoting effect on intestinal mucosal immunity. The results showed that masson pine pollen polysaccharides could enhance mucosal immunity and promote the development of intestinal villi.
Antiaging effect of pine pollen in human diploid fibroblasts and in a mouse model induced by D-galactose
The purpose of this study was to study the anti-aging effect of pine pollen on human diploid fibroblast 2BS cells and to establish an accelerated aging model in c57bl/6j mice after subcutaneous injection of D-galactose for 8 weeks. Pine pollen inhibited the increase of ages level induced by D-galactose, thus reversing the aging phenotype of model mice. In addition, pine pollen treatment significantly reversed the decline of antioxidant activity, which may be the reason for its inhibition of non enzymatic glycosylation (NEG) in vivo. The results show that pine pollen is a potential attractant for delaying aging and alleviating human age-related diseases.
Immunomodulatory effects of sulfated polysaccharides of pine pollen on mouse macrophages
The purpose of this study was to investigate the effects of sulfated polysaccharides from Masson Pine Pollen on [ca (2+)]i and immune function of RAW264.7 macrophages. The results showed that sulfated polysaccharides mainly bound to TLR4 on macrophages. This activates the tlr4-pi3k-plc-ip3r signaling pathway, resulting in calcium release, activating the opening of calcium channels, increasing [ca (2+)]i and activating macrophages, thereby improving immunity.
Effects of Pinus massoniana pollen polysaccharides on intestinal microenvironment and colitis in mice
Pinus massoniana pollen polysaccharides isolated from Pinus massoniana pollen in Taishan have a wide range of biological activities, including immune regulation. The results show that Pinus massoniana pollen polysaccharide has a practical regulatory role in the intestinal microenvironment, which provides a necessary theoretical basis for us to further develop the potential application value of Pinus massoniana pollen polysaccharide.
There are more researches on pine pollen powder are included in the website of National Library of Medicine. You could search for further reading if you want to know more about the pine pollen.