Cordyceps Beta Glucan, Cordyceps Militaris Extract Beta D Glucan powder, β-glucan 30%
【Botanical source】: Cordyceps Militaris
【Extraction source】: Fruiting body
【Specification】: Beta d glucan, β-glucan 30%
【Appearance】: Brownish yellow powder
【Particle size】: 95% pass 80 mesh size
【Components of Cordyceps militaris】: Cordyceps militaris fruitbodies contain nucleosides, cordycepin and adenosine, and the content of these components is higher than that of Cordyceps sinensis. The analysis results show that the following bioactive substances exist in Cordyceps militaris: γ- Aminobutyric acid (GABA) and ergic acid; Glycolipids (cerebrosides), glycoproteins (lectins), D-Mannitol (called endofatty acids), lutein (including carotenoids (lutein and zeaxanthin), sterols (ergosterol), statins (lovastatin), phenolic compounds (including phenolic acids and flavonoids), vitamins and biominerals / biological elements (magnesium, potassium, selenium and sulfur).

Cordyceps Beta Glucan Production Flowchart

Dried Cordyceps Militaris frutingbody – natural air drying–Coarse powder(40 mesh) — Low temperature water extraction – centrifugal filtration – concentration – purification(ultrafiltration membrane, macroporous resin) – spray drying – screening – packaging – detection of physical and chemical indicators – warehousing

Specification of Cordyces Militaris Beta Glucan

Extended Reading
Basic Information

Cordyceps militaris is a fungus of ergot family and Cordyceps genus. Cordyceps militaris is a complex composed of two parts: the seed seat (the grass part) and the sclerotia (the corpse part). One or several of the seats grow from the head of the host, sometimes from the somite, orange yellow, generally unbranched, sometimes branched, 3~5 cm high, the head is rod-shaped, 1~2 cm long, 3~5 mm thick, and the surface is rough. The capsule shell is exposed, nearly conical, and the lower part is embedded in the outer layer of the head, 400~500 μ M × 4-5 μ m, containing 8 bar shaped spores. The spores are slender, almost full of Ascomycetes, about 1 micron thick. When they mature, they produce transverse septa and break into small segments 2~3 microns long. The handle of the pedestal is nearly cylindrical, 2.5~4 cm long and solid inside.

Cordyceps militaris parasitized on the cocoons and pupae of Lepidoptera larvae; It mostly occurs in the forest litter. Wild Cordyceps militaris is distributed all over the world. It is mainly distributed in Yunnan, Anhui, Fujian, Gansu, Guangdong, Guangxi, Guizhou, Hebei, Heilongjiang, Hubei, Jilin, Liaoning, Inner Mongolia, Shandong, Shaanxi, Sichuan, Taiwan, Tibet, Zhejiang and other places in China.

Cordyceps militaris is a edible and medicinal fungus. Its protein content is as high as 40.7%. It contains not only a complete range of essential amino acids, sufficient quantities, but also an appropriate proportion. Cultivated Cordyceps militaris is also rich in vitamins and minerals, which has good edible value. Cordyceps militaris zizuo can be used as medicine. It is mild in nature, sweet in taste, beneficial to the lung and kidney, hemostatic and expectorant. It can generally be used for tuberculosis, old people’s weakness, anemia and other diseases. Cordyceps militaris is rich in cordycepin, cordycepin, ergosterol, etc. it has the functions of expanding trachea, calming, resisting various bacteria and lowering blood pressure.

Medicinal history of Cordyceps militaris

The natural wild Cordyceps sinensis was first published in the outline of Xinhua materia medica. Its “sweet taste and flat nature” has the effect of “benefiting the lung and kidney, tonifying the essence, hemostasis and resolving phlegm”. According to the Chinese medicine sea, a masterpiece of modern Chinese medicine, “Cordyceps militaris, also known as North Cordyceps (Jilin) It is sweet and mild in nature and has two channels of lung and kidney. Main indications: 1. tonifying the kidney and Yang. This product is Gan Ping, tonifying the kidney yang and benefiting the essence. It can be used to treat kidney yang deficiency, marrow sea emptiness, dizziness and tinnitus, forgetfulness and sleeplessness, weak waist and knees, impotence and premature ejaculation, etc. 2. hemostasis and expectoration. This product can Tonify Kidney Yang, benefit lung yin, protect lung and kidney, secrete meridians and replenish qi. It has a good effect on patients with insufficient lung and kidney, long cough and asthma, and cough with phlegm and blood. “. In addition, the national collection of Chinese herbal medicine records that “the fruiting body and insect body of Cordyceps militaris can also be used as Cordyceps sinensis for medicine”.

In 1951, Cunningham, Canada, purified a crystal from Cordyceps militaris and named it cordycepin. In the 1960s, Canada, the United States, Germany and other countries carried out various studies on Cordyceps militaris and published the effects of cordycepin on anti-tumor and anti-virus. In 1990, Japan established the “Cordyceps militaris Research Association” to communicate with Chinese medical experts, and wrote a special book “the efficacy of new Chinese medicine Cordyceps militaris”. Cordycepin can interfere with the synthesis of RNA and DNA in cells, inhibit the division of abnormal cells (cancer cells) and act as a tool to distinguish different RNA polymerases in cells, which has attracted great attention in the medical community. In the United States, cordycepin, as a new anticancer and antiviral drug, has entered phase III clinical practice.

Chemical Composition
Cordyceps Polysaccharide

A galactomannan cm-1 containing a small amount of protein was isolated from the crude polysaccharide of Cordyceps sinensis mycelium culture medium. The molecular weight was 270u, and the molar ratio of galactose to mannose was 6:5. The results show that cm-1 has a highly branched structure, and the branched chain is composed of a large number of β- (1 → 6) galactose and a large amount of β- (1 → 2) furan galactose, connected to 0 ~ 4 and 0 ~ 6 of the trunk respectively. Binwen et al. Isolated and purified Cordyceps militaris Polysaccharide (cmeps) from cultured Cordyceps militaris, which is a glycoprotein containing mannose galactose and galacturonic acid glycan, with a molecular weight of 30 μ， The molar ratio of rhamnose, xylose, mannose, glucose and galactose was 1.00:0.50:51.99:2.38:36.50, and the content of binding protein was 24.17%. Recent studies have found that polysaccharides can significantly activate the reticuloendothelial system and macrophages. It can promote lymphocyte transformation. It is a non-specific immune enhancer and regulator. It can activate the immune active cells of the body, especially lymphocytes and lymphokines, monocyte macrophage system and NK cells, so as to attack the target cells to play an anti-tumor role. At the same time, it has anti-aging, anti-oxidation, anti coagulation, hypoglycemic, hypolipidemic and other functions. It can improve immunity, improve liver function and delay aging.

Sugar alcohols and sterols

D-Mannitol, ergosterol and their peroxides have been identified in Cordyceps militaris β- Sitosterol, aloitol, etc. Among them, D-Mannitol (D-Mannitol) has the functions of anti free radical and anti-oxidation. It is an important raw material in the pharmaceutical industry. It is clinically used to treat cerebral thrombosis, cerebral embolism, vasospasm and renal failure. It has the functions of diuresis, eliminating toxins and promoting metabolism. In addition, ergosterol is a characteristic alcohol of fungi. The content of ergosterol in Cordyceps militaris is relatively constant. Ergosterol has the functions of anti-cancer, anti-aging and detoxification.

SOD enzyme (superoxide dismutase)

It is a bioactive protein. The content of Cordyceps militaris is higher than that of Cordyceps sinensis. This enzyme has the ability to scavenge superoxide anion free radicals produced in metabolism and plays an important role in maintaining the balance of active oxygen metabolism. Sod is the key enzyme in the prevention of various diseases and anti-aging defense substances. In recent years, sod has been widely used and played an important role in many fields, such as food, cosmetics, medicine and health.

Inorganic elements

36 kinds of inorganic elements have been detected in Cordyceps militaris. The kinds of inorganic elements in cultured Cordyceps militaris are basically the same as that in Cordyceps sinensis, and the content is very rich. The World Health Organization has announced that Fe, Cu, Zn, Mn, Cr, Se and Co are necessary for human nutrition. Research shows that deficiency syndrome is related to Fe, Cu, Zn and Mn. Cordyceps sinensis can tonify the lung and kidney, nourish and strengthen the body. The high content of Fe and Mn may be the reason. The human nervous system contains a lot of phospholipids, and Cordyceps sinensis is rich in phosphorus, which may be related to clinical hypnosis, sedation and other nerve regulation; The content of phosphorus in Cordyceps pernyi is 3.5 times that of Cordyceps sinensis. Selenium is the king of anticancer trace elements. The content of selenium in Cordyceps pernyi is 0.54ppm, which is 5.8 times higher than that of Astragalus membranaceus, a selenium rich anticancer drug. According to the literature, when zn/cu in human body reaches 1:14, the cholesterol in human body increases and is prone to coronary heart disease. The zn/cu ratio of Cordyceps militaris, which is considered to be beneficial to the prevention and treatment of coronary heart disease, is 4.5 ~ 5.0.

Other ingredients

Cordyceps militaris also contains palmitic acid, palmitic acid ethyl ester, oleic acid ethyl ester and linoleic acid. Zhangxianke et al. Analyzed the components of the artificially cultivated Cordyceps militaris. The results showed that the protein content was 26%, the fat content was 2.9%, and the sugar content was 28%. The crude protein content of Cordyceps militaris is more than 2 times that of Cordyceps sinensis. High protein content and low fat content indicate that Cordyceps militaris is a good tonic with high protein and low fat. And 18 kinds of amino acids were detected, the total content was up to 1145mg/ 100g, of which the content of 8 kinds of amino acids necessary for human body was very high, and the proportion was appropriate. In addition, Cordyceps militaris also contains a variety of vitamins, including vitamin A, vitamin B12, vitamin B2 and vitamin B1, vitamin B6, vitamin C, vitamin D, vitamin E, niacin, carotene, etc. It is worth mentioning that Wang Gang and others also isolated the compound cerebroside B from Cordyceps militaris. Cerebrosides are components of animal and plant cells and play a key role in cell recognition and binding. Cerebroside B also has anti-cancer, anti-virus (hepatitis virus) and immune enhancement functions.

Pharmacological action
Effect on central nervous system

Cordyceps militaris contains 8 kinds of vitamins, which can regulate the nervous system, have peripheral anticholinergic effect on the autonomic nervous system, reduce the excitability of parasympathetic nerve, make Cordyceps militaris have sedative effect, and have better therapeutic effect on palpitations and insomnia. The results showed that Cordyceps militaris could significantly reduce the spontaneous activity of mice, antagonize the convulsion induced by pentylenetetrazol and induce sleep in mice with pentobarbital sodium to a certain extent. The intensity of action was similar to that of Cordyceps militaris, indicating that Cordyceps militaris had sedative and hypnotic effects, but whether its mechanism was related to the release of GABA transmitters remains to be further studied. Chenguibao et al. Studied the pharmacological effects of the decoction of Cordyceps militaris. The results showed that Cordyceps militaris had obvious sedative and pentobarbital sleep enhancing effects.

Effect on immune system

The immune function of Cordyceps militaris is mainly related to Cordyceps polysaccharide. Studies have shown that different components of Cordyceps polysaccharide can increase the weight of thymus and spleen in mice, and improve the body’s humoral and cellular immunity. Both intracellular and extracellular polysaccharides of Cordyceps militaris can significantly improve the phagocytic rate and phagocytic index of mouse peritoneal macrophages. The enhancement of phagocytic function represents the enhancement of nonspecific immunity. In addition, Cordyceps polysaccharide can significantly enhance the activity of serum lysozyme, increase the activity of SOD in mouse liver red blood cells, promote the formation of red blood cell C3b rosette, and resist the decrease of peripheral white blood cell number caused by cyclophosphamide. Cordyceps polysaccharide CP has bidirectional immunoregulatory effect on human peripheral blood lymphocytes (PBL).

Effect on respiratory system

The research results and clinical experiments show that Cordyceps militaris has a good effect on cough due to lung deficiency, acute and chronic bronchitis and asthma. Dai Ying et al. Studied the extract of Cordyceps militaris by using the mouse lung pathological model of acute endotoxin injury, and found that it can reduce the content of leukocytes and granulocytes and protease activity in lung lavage fluid, and increase the number of lymphocytes and monocytes. It shows that Cordyceps militaris extract can alleviate lung inflammation caused by endotoxin or similar substances by regulating the immune function of body tissues, and has a certain protective effect on the lung.

Anti oxidation and anti-aging effects

Studies have proved that Cordyceps militaris has obvious anti-aging effect, and the effective rate for Alzheimer’s disease is 37.14%, which is significantly better than vitamin E; At the same time, it can increase the activities of SOD, GSH PX and significantly reduce the content of LPO in aged rats, which suggests that the anti-aging effect of Cordyceps militaris is realized through antioxidant effect. Cordycepin in Cordyceps militaris can remove human free radicals, significantly antagonize the production of lipid peroxide in tissue homogenate, significantly increase cell energy charge, reduce blood pressure, expand cardiovascular and cerebrovascular vessels, regulate blood viscosity, inhibit the deposition of lipids in blood and vascular wall, and also protect myocardium. Shenqiying et al. Studied the antioxidant effect of Cordyceps militaris extract through in vivo experiments using the acute inhalation model of n-hexane. The results showed that Cordyceps militaris has the ability to antagonize the damage reaction of active oxygen free radicals induced by hexane proved that Cordyceps militaris extract had anti lipid peroxidation effect.

Effect on reproductive system

Cordyceps militaris can increase testicular spermatogenesis and endocrine function, repair testicular dysfunction caused by adenine, increase serum testosterone content of rats, significantly increase their body weight and the weight of skin gland, seminal vesicle and prostate gland, enhance the weight of castrated rats, and have obvious androgen like effect. The artificially cultivated Cordyceps sinensis fine powder and composite powder can promote the synthesis and secretion of androgens by increasing the enzyme activity of Leydig cells in different degrees, so as to promote the growth and development of testicular spermatogenic cells and the formation of spermatozoa, and play its role of tonifying kidney, Yang and essence. Clinical experiments have proved that Cordyceps militaris has a good therapeutic and health care effect on impotence and premature ejaculation caused by kidney deficiency, and also has a good therapeutic effect on kidney deficiency lumbago, diabetes, proteinuria and other patients with renal dysfunction.

Anti tumor effect

Cordyceps militaris has inhibitory effect on S180 tumor mass and Lewis lung cancer in mice, which can slow down the growth of tumor, reduce the weight, prolong the life of tumor bearing mice and improve the survival rate; And it can significantly reduce the number of spontaneous lung metastases of Lewis lung cancer and reduce the rate of lung metastasis in mice. Cordycepin injection can prolong the survival time of Ehrlich ascites tumor mice. In addition to its direct inhibition of cell division and anticancer effects, it can also enhance the host specific immune function and obtain significant immune effects. In addition, Cordyceps militaris has good antitumor effects on human melanoma B16 cells, human leukemia HL-60 cells, human nasopharyngeal carcinoma (KB) cells and human erythroleukemia K562 cells.

Toxicity study

Safe, effective and controllable is one of the most important contents in drug research and development. There are many kinds of Cordyceps, some of which are toxic and difficult to be used as substitutes for Cordyceps. The experiment proved that the oral LD50 of female and male of Cordyceps militaris Dahe mice was greater than 10.0g/kg body weight. According to the classification standard of acute toxicity, the acute oral toxicity of Cordyceps militaris Dahe and mice belonged to the actual non-toxic category, and the carcinogenic, teratogenic and mutagenic tests were negative. Another study found that no obvious toxic reaction was found in all indicators of the 30 day feeding experiment of rats, and the maximum non side effect dose was 4.0g/kg body weight, which fully showed that Cordyceps sinensis was safe.